Rapor Tarihi: 11.04.2026 00:52
| Course Title | Code | Language | Type | Semester | L+U Hour | Credits | ECTS |
|---|---|---|---|---|---|---|---|
| Cytogenetic | TBG507 | Turkish | Compulsory | 3 + 4 | 5.0 | 8.0 |
| Prerequisite Courses | |
| Course Level | Graduate |
| Mode of delivery | Face-to-face; theoretical lectures, intensive laboratory applications (cell culture and microscopic analyses), case presentations, and literature discussions. |
| Course Coordinator | Prof. Dr. Hüseyin YÜCE |
| Instructor(s) | |
| Goals | To teach the fundamental principles of classical and molecular cytogenetic methods; to provide advanced skills in chromosome analysis, karyotyping, and the applications of chromosomal abnormalities in clinical diagnosis. |
| Course Content | Cell culture techniques; chromosome harvesting and staining (banding) methods; numerical and structural chromosomal irregularities; molecular cytogenetics (FISH, mFISH, array-CGH); prenatal and postnatal cytogenetic diagnosis; cancer cytogenetics, and current technological developments. |
| # | Öğrenme Kazanımı |
| 1 | Explains advanced cell culture, chromosome harvesting, and classical banding methods and applies them in a laboratory setting. |
| 2 | Analyzes human chromosomes according to ISCN (International System for Human Cytogenomic Nomenclature) standards and reports numerical and structural abnormalities using correct terminology. |
| 3 | Comprehends the molecular mechanisms of chromosomal abnormalities and makes diagnostic interpretations by correlating these findings with clinical conditions. |
| 4 | Analyzes the principles of advanced molecular cytogenetic techniques such as FISH, mFISH, and Array-CGH, and gains the ability to select these methods for appropriate indications. |
| 5 | Analyzes complex cases encountered in prenatal, postnatal, and cancer cytogenetics and develops evidence-based solution proposals. |
| 6 | Ensures full compliance with biosafety rules, quality control standards, and medical ethical principles in laboratory processes. |
| 7 | Follows current literature and technological developments in the field and presents the gathered data in an academic language both in written and oral formats. |
| Week | Topics/Applications | Method |
|---|---|---|
| 1. Week | Fundamentals and History of Cytogenetics | Lecture, Discussion |
| 2. Week | Structure and Organization of Human Chromosomes | Practice, Lecture, Discussion |
| 3. Week | Cell Culture and Chromosome Harvesting | Practice |
| 4. Week | Classical Banding Methods (G, R, Q, C Banding) | Practice, Lecture |
| 5. Week | Nomenclature: ISCN Rules and Writing Standards | Lecture, Discussion |
| 6. Week | Numerical Chromosome Abnormalities | Lecture |
| 7. Week | Structural Chromosome Abnormalities | Lecture, Discussion |
| 8. Week | Introduction to Molecular Cytogenetics: FISH Technique | Practice, Lecture |
| 9. Week | Multicolor FISH and Comparative Genomic Hybridization | Practice, Lecture, Discussion |
| 10. Week | Array-CGH Technology and Data Analysis | Practice, Lecture |
| 11. Week | Prenatal and Preimplantation Genetic Diagnosis | Practice, Lecture, Discussion |
| 12. Week | Postnatal Diagnosis and Clinical Correlation | Practice, Lecture, Discussion |
| 13. Week | Cancer Cytogenetics and Solid Tumors | Practice, Lecture, Discussion |
| 14. Week | Next-Generation Technologies and Automation in Cytogenetics | Practice, Lecture, Discussion |
| No | Program Requirements | Level of Contribution | |||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Advanced Field Knowledge: Deeply comprehends and evaluates up-to-date and advanced theoretical and practical knowledge in the field of medical biology and genetics. | ✔ | |||||
| 7 | Academic and Professional Ethics: Observes universal ethical principles and legal regulations during the planning, execution, and reporting phases of scientific research. | ✔ | |||||
| 9 | Independent Work and Responsibility: Independently plans, manages, and concludes an advanced study related to the field. | ✔ | |||||
| 10 | Lifelong Learning: Continuously improves knowledge and skills by following technological innovations and current developments in the field. | ✔ | |||||
| Program Requirements | DK1 | DK2 | DK3 | DK4 | DK5 | DK6 | DK7 |
|---|---|---|---|---|---|---|---|
| PY1 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| PY7 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| PY9 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| PY10 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| Ders Kitabı veya Notu | Ders Kitabı veya Ders Notu bulunmamaktadır. |
|---|---|
| Diğer Kaynaklar |
|
| ECTS credits and course workload | Quantity | Duration (Hour) | Total Workload (Hour) | |
|---|---|---|---|---|
|
Ders İçi |
Class Hours | 14 | 7 | 98 |
|
Ders Dışı |
Preparation, After Class Study | 14 | 3 | 42 |
| Presentation (Preparation) | 1 | 15 | 15 | |
| Practice | 10 | 4 | 40 | |
|
Sınavlar |
Midterm | 1 | 2 | 2 |
| Midterm Preparation | 1 | 12 | 12 | |
| Final | 1 | 2 | 2 | |
| Practice | 1 | 18 | 18 | |
| Total Workload | 229 | |||
| *AKTS = (Total Workload) / 25,5 | ECTS Credit of the Course | 8.0 | ||
