Rapor Tarihi: 22.12.2025 23:10
| Course Title | Code | Language | Type | Semester | L+U Hour | Credits | ECTS |
|---|---|---|---|---|---|---|---|
| Myocardial Ischemia and Reperfusion Injury | BIO633 | Turkish | Compulsory | 2 + 2 | 3.0 | 8.0 |
| Prerequisite Courses | |
| Course Level | Graduate |
| Mode of delivery | Face to Face |
| Course Coordinator | Doç. Dr. Salih Tunç KAYA |
| Instructor(s) | |
| Goals | The aim of this course is to provide general information about cellular changes and their mechanisms as a result of myocardial ischemia and reperfusion injury, as well as arrhythmias and infarction. |
| Course Content | Introduction to ischemia–reperfusion injury, Myocardial ischemia, Myocardial reperfusion, Myocardial ischemia/reperfusion injury: Mechanisms of injury and implications for management , Cardio protection, Ischemic preconditioning, Ischemic postconditioning, Experimental models for ischemia–reperfusion injury, Myocardial ischemia/reperfusion injury: Apoptosis, Myocardial ischemia/reperfusion injury: Necrosis, Myocardial ischemia/reperfusion injury: Ferroptosis, Current Strategies to Reduce Ischemic Damage and Reperfusion injury, Mitochondrial Dysfunction and Myocardial ischemia/reperfusion injury, MicroRNAs and Myocardial ischemia/reperfusion injury |
| # | Öğrenme Kazanımı |
| 1 | Know myocardial ischemia and reperfusion damage both experimentally and theoretically. |
| 2 | Explain the cellular mechanism of damage. |
| 3 | Can identify arrhythmia and infarction. |
| Week | Topics/Applications | Method |
|---|---|---|
| 1. Week | Introduction to ischemia–reperfusion injury | Preparation, After Class Study, Research, Interview, Presentation (Preparation), Practice |
| 2. Week | Myocardial ischemia | Preparation, After Class Study, Research, Other Activities, Interview, Presentation (Preparation), Practice |
| 3. Week | Myocardial reperfusion | Preparation, After Class Study, Research, Other Activities, Interview, Presentation (Preparation), Practice |
| 4. Week | Myocardial ischemia/reperfusion injury: Mechanisms of injury and implications for management | |
| 5. Week | Cardioprotection mechanisms | Preparation, After Class Study, Research, Other Activities, Interview, Presentation (Preparation), Practice |
| 6. Week | Ischemic preconditioning | |
| 7. Week | İschemic postconditioning | Preparation, After Class Study, Research, Interview, Presentation (Preparation), Practice |
| 8. Week | Experimental models for ischemia–reperfusion injury / Mid Term | Preparation, After Class Study, Research, Interview, Presentation (Preparation), Practice |
| 9. Week | Myocardial ischemia/reperfusion injury: Apoptosis | Preparation, After Class Study, Research, Interview, Presentation (Preparation), Practice |
| 10. Week | Myocardial ischemia/reperfusion injury: Necrosis | Preparation, After Class Study, Research, Interview, Presentation (Preparation), Practice |
| 11. Week | Myocardial ischemia/reperfusion injury: Ferroptosis | Preparation, After Class Study, Research, Interview, Presentation (Preparation), Practice |
| 12. Week | Current Strategies to Reduce Ischemic Damage and Reperfusion Injury | Preparation, After Class Study, Research, Interview, Presentation (Preparation), Practice |
| 13. Week | Mitochondrial Dysfunction and Myocardial ischemia/reperfusion injury | Preparation, After Class Study, Research, Interview, Presentation (Preparation), Practice |
| 14. Week | MicroRNAs and Myocardial ischemia/reperfusion injury | Preparation, After Class Study, Research, Interview, Presentation (Preparation), Practice |
| No | Program Requirements | Level of Contribution | |||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | Improve the scientific knowledge in the field of Biology to a more advanced level. Use the advenced knowledge to innovate, interpret the results, to apply the results and to design unique projects | ✔ | |||||
| 2 | Gain the ability to identify scientific questions, compare, analyze and solve the problems independently. | ✔ | |||||
| 3 | Gain the skills of using the modern laboratory techniques and analysis methods in the field of biology. | ✔ | |||||
| 4 | Gain the ability to get the information by doing research, to evaluate, interpret and apply it. | ✔ | |||||
| 5 | Gain the ability of discussion, synthesis and applying the scientific knowledge. | ✔ | |||||
| 6 | Gain the ability to design experimental studies, do the applications and analyse the complicated results using advanced skills, like critical thinking, problem solving and deciding. | ✔ | |||||
| 7 | Use the scientific knowledge and apply the ability of problem solving, evaluate and analyse advanced concepts in interdiciplinary fields. | ✔ | |||||
| 10 | Follow the innovations in the field of biology. Gain the ability to find resources and to use the databases. | ✔ | |||||
| 11 | Find new or strategical approaches to solve an unpredicted or advanced problems. | ✔ | |||||
| 12 | Improve scientific knowledge where there is a little or limited data present. Gain the ability to connect the information from different scientific diciplines. | ✔ | |||||
| 13 | Find unique ideas and get in contact with the professionals in scientific topics using his/her knowledge and skills. | ✔ | |||||
| 14 | Have the ability to read, understand, speak and write a foreign language in order to contact with the scientists from all over the World. | ✔ | |||||
| 15 | Follow novel developments in computational software and hardware systems related with biology, use this knowledge and skill in research. | ✔ | |||||
| 16 | Obey the ethical regulations and watch the ethical issues while designing a scientific study, collecting data, evaluating and publishing them. | ✔ | |||||
| 17 | Adopt life-long learning strategies during performing scientific studies. | ✔ | |||||
| Program Requirements | DK1 | DK2 | DK3 |
|---|---|---|---|
| PY1 | 4 | 4 | 4 |
| PY2 | 5 | 5 | 5 |
| PY3 | 5 | 5 | 5 |
| PY4 | 4 | 4 | 4 |
| PY5 | 5 | 5 | 5 |
| PY6 | 5 | 5 | 5 |
| PY7 | 5 | 5 | 5 |
| PY10 | 5 | 5 | 5 |
| PY11 | 5 | 5 | 5 |
| PY12 | 5 | 5 | 5 |
| PY13 | 5 | 5 | 5 |
| PY14 | 5 | 5 | 5 |
| PY15 | 4 | 4 | 4 |
| PY16 | 5 | 5 | 5 |
| PY17 | 5 | 5 | 5 |
| Ders Kitabı veya Notu | Ders Kitabı veya Ders Notu bulunmamaktadır. |
|---|---|
| Diğer Kaynaklar |
|
| ECTS credits and course workload | Quantity | Duration (Hour) | Total Workload (Hour) | |
|---|---|---|---|---|
|
Ders İçi |
Class Hours | 14 | 2 | 28 |
|
Ders Dışı |
Preparation, After Class Study | 14 | 2 | 28 |
| Research | 14 | 2 | 28 | |
| Interview | 14 | 3 | 42 | |
| Presentation (Preparation) | 14 | 3 | 42 | |
| Practice | 14 | 2 | 28 | |
|
Sınavlar |
Midterm 1 | 1 | 2 | 2 |
| Final | 1 | 2 | 2 | |
| Classroom Activities | 4 | 1 | 4 | |
| Total Workload | 204 | |||
| *AKTS = (Total Workload) / 25,5 | ECTS Credit of the Course | 8.0 | ||
