Course Information

Course Information
Course Title Code Language Type Semester L+U Hour Credits ECTS
Pharmaceutical Chemistry I Laboratory ECZ393 Turkish Compulsory 5. Semester 0 + 4 2.0 3.0
Prerequisite Courses
Course Level Undergraduate
Mode of delivery face to face
Course Coordinator Dr. Öğr. Üyesi Bahadır BÜLBÜL
Instructor(s) Dr. Öğr. Üyesi Bahadır BÜLBÜL (Güz)
Goals The aim of this course is to provide students with knowledge of laboratory safety, laboratory working techniques such as filtration, extraction, distillation, etc., and the synthesis and purification of some drug active ingredients and excipients under laboratory conditions, such as esterification, acylation, nitration, bromination, oxidation, diazo formation, etc.
Course Content
Learning Outcomes
# Öğrenme Kazanımı
1 • Evaluates the stages of developing a new drug active ingredient.
2 • Designs and synthesizes the active pharmaceutical ingredient.
3 • Evaluates production stages on a pilot scale.
4 • Conducts patent searching and evaluation studies related to pharmaceuticals.
5 • Practices pharmacy based on scientific evidence.
Lesson Plan (Weekly Topics)
Week Topics/Applications Method
1. Week Demonstration (Lab Safety) and working techniques Preparation, After Class Study Class Hours Presentation (Preparation) Interview
2. Week Demonstration (Org. Reactions) Interview Presentation (Preparation) Class Hours Preparation, After Class Study
3. Week Distillation studies Presentation (Preparation) Preparation, After Class Study Interview Class Hours
4. Week Fischer esterification reaction Interview Presentation (Preparation) Preparation, After Class Study Class Hours
5. Week Extraction, filtration, crystallisation Presentation (Preparation) Interview Preparation, After Class Study Class Hours
6. Week Cannizaro reaction Presentation (Preparation) Interview Preparation, After Class Study Class Hours
7. Week Aspirin synthesis Presentation (Preparation) Class Hours Preparation, After Class Study Interview
8. Week Obtaining Benzyl by Benzoin Oxidation Presentation (Preparation) Preparation, After Class Study Interview Class Hours
9. Week Benzilic acid rearrangement reaction Class Hours Presentation (Preparation) Preparation, After Class Study Interview
10. Week Fenitoin synthesis Preparation, After Class Study Presentation (Preparation) Interview Class Hours
11. Week Ürotropin synthesis
12. Week İzoniyazid synthesis Class Hours Interview Presentation (Preparation) Preparation, After Class Study
13. Week İproniyazid synthesis Preparation, After Class Study Interview Class Hours Presentation (Preparation)
14. Week Parastemol synthesis Preparation, After Class Study Class Hours Interview Presentation (Preparation)
*Midterm and final exam dates are not specified in the 14-week course operation plan. Midterm and final exam dates are held on the dates specified in the academic calendar with the decision of the University Senate.
The Matrix for Course & Program Learning Outcomes
No Program Requirements Level of Contribution
1 2 3 4 5
1 Uses the knowledge and skills acquired by completing the pharmacy undergraduate programme in the application areas of the profession by taking initiative when necessary within the framework of ethical and deontological rules in line with the current laws, regulations and legislation.
2 Has sufficient knowledge and application skills about the physical and chemical structure, synthesis, microbiological and toxicological analysis, effects, structure-effect relationships, design and development, therapeutic dose determination, pharmacokinetic and pharmacodynamic properties of active and excipients, pharmaceutical preparations and medicinal products.
3 By adopting lifelong learning, pharmacy professional practices, science, technology, contemporary thinking and behaviour in the dimension of current information in the dimension of technological tools, databases and information resources. Develops, deepens, evaluates and uses this information for the benefit of society.
4 Takes an active role in the preparation, production, quality assurance and control, bioavailability and bioequivalence, licensing and patent studies, supply chain management and presentation of pharmaceutical, radiopharmaceutical, biotechnological, nanotechnological and cosmetic/cosmeceutical products containing natural or synthetic active ingredients.
5 Takes an active role in pharmacovigilance practices; uses the adverse effect reporting system; contributes to risk management and audit to ensure safe drug use.
6 Informs the patient, patient relatives and other health professionals to increase awareness of drug safety.
7 He/she has sufficient knowledge about the preparation of major medicines, the use and legislation of all original or generic preparations and medicinal products.
8 Has knowledge about the indications, route of administration and incompatibilities of the drugs prescribed to the patient, evaluation of clinical laboratory results in order to ensure and promote the most appropriate use of drugs within the framework of rational drug use.
9 Food supplements, nutraceuticals, cosmetics / cosmeceuticals, OTC, etc. has the competence to provide practical and useful information to the public about products.
10 Integrates and develops pharmacy professional knowledge with knowledge from different disciplines within the framework of pharmaceutical care and clinical pharmacy practice.
11 To be able to communicate effectively with the relevant legal authorities, physicians and health personnel, pharmaceutical industry and other stakeholders in order to improve the health level and quality of life of the society, and to be able to bring suggestions and solutions to the problems related to the field.
12 Has knowledge about the properties, usage areas, production, quality assurance, legislation and legal regulations of medical devices used for chronic diseases and other purposes.
13 They take part in the supply and presentation of pharmaceuticals and medical products and provide counselling services to patients on rational and safe use.
14 To be able to follow the information and developments in pharmacy practice areas by using at least one foreign language, to communicate with patients and colleagues, to express himself/herself verbally and in writing by participating in national and / or international activities and projects.
15 Has sufficient knowledge and application skills about various technological tools, information resources, software and artificial intelligence supported technologies required by pharmacy professional practice areas.
16 As a health professional providing primary health care services, provides healthy living counselling by managing patient records; promotes healthy living and fulfils professional responsibilities to protect public health.
17 He/she pays attention to the occupational safety of the employees under his/her responsibility and plans and manages their vocational training for their development within the framework of a project and monitors and evaluates the process.
18 Takes part in the development processes of the pharmacy profession and application areas related to pharmaceutical and health management; conducts research and development activities in accordance with scientific and ethical principles; analyses, evaluates, interprets and applies data.
19 Participates in quality management processes by documenting professional activities and practices effectively and safely in accordance with quality management and processes.
20 Be a role model for his/her colleagues and an example to the society with his/her attitude, behaviour and professional identity.
21 Has knowledge about anatomy, immunology, physiology, physiopathology and biochemistry of biological systems. Knows and relates the basic concepts of cognitive states and behaviours, mental and physical diseases, symptoms and treatments that affect human health.
Relations with Education Attainment Program Course Competencies
Program Requirements DK1 DK2 DK3 DK4 DK5
PY1 1 1 1 1 1
PY2 1 1 1 1 1
PY3 4 4 4 4 4
PY4 4 4 4 4 4
PY5 1 1 1 1 1
PY6 1 1 1 1 1
PY7 3 3 3 3 3
PY8 1 1 1 1 1
PY9 1 1 1 1 1
PY10 1 1 1 1 1
PY11 1 1 1 1 1
PY12 1 1 1 1 1
PY13 1 1 1 1 1
PY14 4 4 4 4 4
PY15 4 4 4 4 4
PY16 1 1 1 1 1
PY17 4 4 4 4 4
PY18 4 4 4 4 4
PY19 1 1 1 1 1
PY20 2 2 2 2 2
PY21 1 1 1 1 1
Recommended Sources
Ders Kitabı veya Notu Ders Kitabı veya Ders Notu bulunmamaktadır.
Diğer Kaynaklar
  • Akgün, H., Balkan, A., Bilgin, A.A., Çalış, Ü., Dalkara, S., Erdoğan, H., Erol Demir, D., Ertan, M.,Gökhan, N., Özkanlı, F., Palaska, E., Saraç, S. ve Şafak, C.,Tozkoparan.B.: Farmasötik Kimya, Ankara, 2004.
  • Foye, W.O.(ed): Principles of Medicinal Chemistry, 3rd ed, Lea & Febrigen, Philadelphia, 1989.
  • Delgado, J.N., Remers, W.A. (ed), Wilson & Gisvold?s Textbook of Organic Medicinal and Pharmaceutical Chemistry, 9th ed., Lippincott, Philadelphia, 1991
  • Nicolaou KC. ?Classics in Total Synthesis? NewYork 1996
  • Modern Organic Synthesis in the Laboratory, Oxford University Press, Inc.,2007
ECTS credits and course workload
ECTS credits and course workload Quantity Duration (Hour) Total Workload (Hour)
Ders İçi
Class Hours 14 4 56
Ders Dışı
Preparation, After Class Study 5 3 15
Research 1 3.5 3.5
Sınavlar
Midterm 1 1 1 1
Final 1 1 1
Total Workload 76.5
*AKTS = (Total Workload) / 25,5 ECTS Credit of the Course 3.0