| Course Title | Code | Semester | L+U Hour | Credits | ECTS |
|---|---|---|---|---|---|
| Myocardial Ischemia and Reperfusion Injury | BIO633 | 2 + 2 | 3.0 | 8.0 |
| Prerequisites | None |
| Language of Instruction | Turkish |
| Course Level | Graduate |
| Course Type | |
| Mode of delivery | Face to Face |
| Course Coordinator |
Assoc. Prof. Dr. Salih Tunç KAYA |
| Instructors | |
| Assistants | |
| Goals | The aim of this course is to provide general information about cellular changes and their mechanisms as a result of myocardial ischemia and reperfusion injury, as well as arrhythmias and infarction. |
| Course Content | Introduction to ischemia–reperfusion injury, Myocardial ischemia, Myocardial reperfusion, Myocardial ischemia/reperfusion injury: Mechanisms of injury and implications for management , Cardio protection, Ischemic preconditioning, Ischemic postconditioning, Experimental models for ischemia–reperfusion injury, Myocardial ischemia/reperfusion injury: Apoptosis, Myocardial ischemia/reperfusion injury: Necrosis, Myocardial ischemia/reperfusion injury: Ferroptosis, Current Strategies to Reduce Ischemic Damage and Reperfusion injury, Mitochondrial Dysfunction and Myocardial ischemia/reperfusion injury, MicroRNAs and Myocardial ischemia/reperfusion injury |
| Learning Outcomes |
- Know myocardial ischemia and reperfusion damage both experimentally and theoretically. - Explain the cellular mechanism of damage. - Can identify arrhythmia and infarction. |
| Week | Topics | Learning Methods |
|---|---|---|
| 1. Week | Introduction to ischemia–reperfusion injury | Research Visual Presentation Preparation, After Class Study Verbal Expression Practice Course Hours |
| 2. Week | Myocardial ischemia | Preparation, After Class Study Verbal Expression Visual Presentation Practice Course Hours Other Activities Research |
| 3. Week | Myocardial reperfusion | Visual Presentation Practice Preparation, After Class Study Research Course Hours Verbal Expression Other Activities |
| 4. Week | Myocardial ischemia/reperfusion injury: Mechanisms of injury and implications for management | |
| 5. Week | Cardioprotection mechanisms | Course Hours Preparation, After Class Study Research Verbal Expression Visual Presentation Practice |
| 6. Week | Ischemic preconditioning | |
| 7. Week | İschemic postconditioning | Practice Course Hours Preparation, After Class Study Visual Presentation Research Verbal Expression |
| 8. Week | Experimental models for ischemia–reperfusion injury / Mid Term | Course Hours Preparation, After Class Study Research Practice Visual Presentation Verbal Expression |
| 9. Week | Myocardial ischemia/reperfusion injury: Apoptosis | Visual Presentation Practice Course Hours Research Preparation, After Class Study Verbal Expression |
| 10. Week | Myocardial ischemia/reperfusion injury: Necrosis | Preparation, After Class Study Course Hours Research Visual Presentation Practice Verbal Expression |
| 11. Week | Myocardial ischemia/reperfusion injury: Ferroptosis | Practice Course Hours Research Preparation, After Class Study Visual Presentation Verbal Expression |
| 12. Week | Current Strategies to Reduce Ischemic Damage and Reperfusion Injury | Research Visual Presentation Practice Verbal Expression Preparation, After Class Study Course Hours |
| 13. Week | Mitochondrial Dysfunction and Myocardial ischemia/reperfusion injury | Visual Presentation Practice Course Hours Verbal Expression Research Preparation, After Class Study |
| 14. Week | MicroRNAs and Myocardial ischemia/reperfusion injury | Course Hours Preparation, After Class Study Research Visual Presentation Practice Verbal Expression |
| Pathophysiology of Ischemia Reperfusion Injury and Use of Fingolimod in Cardioprotection,ISBN 978-0-12-818023-5 |
| Myocardial Ischemia and Reperfusion, Hardcover ISBN978-0-7923-8173-0 Published: 31 May 1999 |
| Program Requirements | Contribution Level | DK1 | DK2 | DK3 | Measurement Method |
|---|---|---|---|---|---|
| PY1 | 4 | 0 | 0 | 0 | - |
| PY2 | 5 | 0 | 0 | 0 | - |
| PY3 | 5 | 0 | 0 | 0 | - |
| PY4 | 4 | 0 | 0 | 0 | - |
| PY5 | 5 | 0 | 0 | 0 | - |
| PY6 | 5 | 0 | 0 | 0 | - |
| PY7 | 5 | 0 | 0 | 0 | - |
| PY10 | 5 | 0 | 0 | 0 | - |
| PY11 | 5 | 0 | 0 | 0 | - |
| PY12 | 5 | 0 | 0 | 0 | - |
| PY13 | 5 | 0 | 0 | 0 | - |
| PY14 | 5 | 0 | 0 | 0 | - |
| PY15 | 4 | 0 | 0 | 0 | - |
| PY16 | 5 | 0 | 0 | 0 | - |
| PY17 | 5 | 0 | 0 | 0 | - |
| 0 | 1 | 2 | 3 | 4 | 5 | |
|---|---|---|---|---|---|---|
| Course's Level of contribution | None | Very Low | Low | Fair | High | Very High |
| Method of assessment/evaluation | Written exam | Oral Exams | Assignment/Project | Laboratory work | Presentation/Seminar |
| Event | Quantity | Duration (Hour) | Total Workload (Hour) |
|---|---|---|---|
| Course Hours | 14 | 2 | 28 |
| Preparation, After Class Study | 14 | 2 | 28 |
| Research | 14 | 2 | 28 |
| Verbal Expression | 14 | 3 | 42 |
| Visual Presentation | 14 | 3 | 42 |
| Practice | 14 | 2 | 28 |
| Midterm 1 | 1 | 2 | 2 |
| Final | 1 | 2 | 2 |
| Classroom Activities | 4 | 1 | 4 |
| Total Workload | 204 | ||
| ECTS Credit of the Course | 8.0 | ||
