| Course Title | Code | Semester | L+U Hour | Credits | ECTS |
|---|---|---|---|---|---|
| Pharmaceutical Toxicology 1 | ECZ409 | 7. Semester | 3 + 0 | 3.0 | 3.0 |
| Prerequisites | None |
| Language of Instruction | Turkish |
| Course Level | Undergraduate |
| Course Type | |
| Mode of delivery | Lecture, discussion, question and answer, |
| Course Coordinator |
Assist. Prof. Dr. Didem ORAL |
| Instructors | |
| Assistants | |
| Goals | To have knowledge about the basic concepts of toxicology, toxicity mechanisms, systemic toxic effects and toxic effects of xenobiotics on biological systems |
| Course Content | Introduction to toxicology Toxicological analysis Toxicokinetics Toxicological mechanisms Factors affecting toxicity Classification of the toxic effects Genotoxicology Carcinogenesis and carcinogenic compounds Teratogenicity and using drugs in Allergy and immunotoxic effects Toxicological interactions; Toxicological evaluation of drug-drug, drug-disease, drug-food interactions Effects of genetic polymorphism on toxicity |
| Learning Outcomes |
- 1. To comprehend the basic concepts and principles of toxicology. 2. To learn the toxicokinetics and toxicological mechanisms of drugs, other chemicals, and physical agents 3. To learn general treatment principles and specific antidotes in the poisoning xenobiotics. 4. To learn about specific toxicological effects and toxicological consequences of genetic polymorphism 5. To have knowledge about the genotoxic factors and their mechanisms caused by xenobiotics. 6. To have knowledge about teratogenicity and teratogenic compounds 7. To learn and interpret the toxicological tests 8. To gain awareness about the risks of environmental and occupational exposures. |
| Week | Topics | Learning Methods |
|---|---|---|
| 1. Week | Introduction to toxicology | |
| 2. Week | Toxicokinetics; tranformation of xenobiotics and their effects on toxicity | |
| 3. Week | Toxic mechanisms of action | |
| 4. Week | Factors affecting toxicity | |
| 5. Week | Classification of toxic effects | |
| 6. Week | Genotoxic effect | |
| 7. Week | Carcinogenicity and carcinogenic compounds | |
| 8. Week | Teratogenicity and drug use in pregnancy | |
| 9. Week | Allergic reactions and immunotoxic effect | |
| 10. Week | Toxicologic interactions; toxicologic evaluation of drug-drug, drug-disease, drug-food interactions | |
| 11. Week | Genetic polymorphism and its effects on toxicity | |
| 13. Week | Carcinogenicity and carcinogenic compounds |
| 1.Klaassen, C.D., Watkins J.W., "Casarett & Doull’s Essential of Toxicology, The McGraw Hill Companies, 2010. 2.Ellenhorn, M.J., "Medical Toxicology", Williams & Wilkins, Maryland, 1997. 3.Hayes, A.W., "Principles and Methods of Toxicology", Taylor & Francis, Philadelphia, 2001.3. Toksikolojinin Temelleri ("Casarett & Doull’s çeviri) Nobel Kitapevi, 2017 |
| Program Requirements | Contribution Level | DK1 | Measurement Method |
|---|
| 0 | 1 | 2 | 3 | 4 | 5 | |
|---|---|---|---|---|---|---|
| Course's Level of contribution | None | Very Low | Low | Fair | High | Very High |
| Method of assessment/evaluation | Written exam | Oral Exams | Assignment/Project | Laboratory work | Presentation/Seminar |
| Event | Quantity | Duration (Hour) | Total Workload (Hour) |
|---|---|---|---|
| Midterm 1 | 1 | 1.5 | 1.5 |
| Homework 1 | 13 | 1 | 13 |
| Homework 2 | 13 | 1 | 13 |
| Quiz 1 | 10 | 1 | 10 |
| Quiz 2 | 9 | 1 | 9 |
| Final | 1 | 2 | 2 |
| Classroom Activities | 14 | 2 | 28 |
| Total Workload | 76.5 | ||
| ECTS Credit of the Course | 3.0 | ||
