| Course Title | Code | Semester | L+U Hour | Credits | ECTS |
|---|---|---|---|---|---|
| Pharmaceutical Toxicology 2 | ECZ408 | 8. Semester | 3 + 0 | 3.0 | 3.0 |
| Prerequisites | None |
| Language of Instruction | Turkish |
| Course Level | Undergraduate |
| Course Type | |
| Mode of delivery | Lecture, discussion, question and answer, |
| Course Coordinator |
Assist. Prof. Dr. Didem ORAL |
| Instructors | |
| Assistants | |
| Goals | To have knowledge about the basic concepts of toxicology, toxicity mechanisms, systemic toxic effects and toxic effects of xenobiotics on biological systems |
| Course Content | Target Organ Toxicity (I): Hepatoxicity, Nephrotoxicity and Skin Toxicity Target Organ Toxicity (2): Pulmonary System Toxicity, Hematotoxicity Target Organ Toxicity (3): Central nervous system toxicity, Allergic reactions and immunotoxic effect Selective Toxicity and Pesticide Toxicology Toxicological Evaluation of Biotechnological Products Introduction to Environmental Toxicology and Disaster Toxicology Heavy Metal Toxicity: Lead, Mercury, Arsenic and Cadmium Toxic effects of non-steroidal anti-inflammatory drugs Toxins in Food: Mycotoxins, Botulinum Animal Poisoning, Mushroom Poisoning, Reliability of Chemical Substances Used Indoors Toxic Effects of Antidepressant Drugs Toxic Effects of Vitamins Toxic Effects of Antihypertensive Drugs |
| Learning Outcomes |
- 1. To understand the basic concepts and principles of toxicology. 2. To learn toxicokinetics and toxic mechanisms of action of drugs and other chemical and physical agents 3. To learn general treatment principles and specific antidotes in poisoning with xenobiotics including drugs 4. To learn specific toxic effects and toxic consequences of genetic polymorphism 5. To have knowledge about genotoxic factors and mechanisms of genotoxic effects caused by drugs, physical and chemical agents. 6. To have knowledge about teratogenicity and teratogenic compounds 7. To learn the tests for toxic effect types, to interpret the results 8. To gain awareness of the risks that may occur as a result of drugs, environmental and occupational exposure |
| Week | Topics | Learning Methods |
|---|---|---|
| 1. Week | Target Organ Toxicity (I): Hepatoxicity, Nephrotoxicity and Skin Toxicity | |
| 2. Week | Target Organ Toxicity (2): Pulmonary System Toxicity, Hematotoxicity | |
| 3. Week | Target Organ Toxicity (3): Central nervous system toxicity | |
| 4. Week | Allergic reactions and immunotoxic effect | |
| 5. Week | Selective Toxicity and Pesticide Toxicology | |
| 6. Week | Toxicological Evaluation of Biotechnological Products | |
| 7. Week | Introduction to Environmental Toxicology and Disaster Toxicology | |
| 9. Week | Heavy Metal Toxicity: Lead, Mercury, Arsenic and Cadmium | |
| 10. Week | Toxic effects of non-steroidal anti-inflammatory drugs | |
| 11. Week | Toxins in Food: Mycotoxins, Botulinum Animal Poisoning, Mushroom Poisoning, Reliability of Chemical Substances Used Indoors | |
| 13. Week | Toxic Effects of Antidepressant Drugs | |
| 13. Week | Toxic Effects of Vitamins | |
| 14. Week | Toxic Effects of Antihypertensive Drugs |
| 1.Klaassen, C.D., Watkins J.W., "Casarett & Doull’s Essential of Toxicology, The McGraw Hill Companies, 2010. 2.Ellenhorn, M.J., "Medical Toxicology", Williams & Wilkins, Maryland, 1997. 3.Hayes, A.W., "Principles and Methods of Toxicology", Taylor & Francis, Philadelphia, 2001. |
| Program Requirements | Contribution Level | DK1 | Measurement Method |
|---|
| 0 | 1 | 2 | 3 | 4 | 5 | |
|---|---|---|---|---|---|---|
| Course's Level of contribution | None | Very Low | Low | Fair | High | Very High |
| Method of assessment/evaluation | Written exam | Oral Exams | Assignment/Project | Laboratory work | Presentation/Seminar |
| Event | Quantity | Duration (Hour) | Total Workload (Hour) |
|---|---|---|---|
| Midterm 1 | 1 | 1.5 | 1.5 |
| Homework 1 | 13 | 1 | 13 |
| Homework 2 | 13 | 1 | 13 |
| Quiz 1 | 10 | 1 | 10 |
| Quiz 2 | 9 | 1 | 9 |
| Final | 1 | 2 | 2 |
| Classroom Activities | 14 | 2 | 28 |
| Total Workload | 76.5 | ||
| ECTS Credit of the Course | 3.0 | ||
