| Course Title | Code | Semester | L+U Hour | Credits | ECTS |
|---|---|---|---|---|---|
| Bıopharmaceutıcs And Pharmacokınetıcs | ECZ404 | 8. Semester | 2 + 0 | 2.0 | 3.0 |
| Prerequisites | None |
| Language of Instruction | Turkish |
| Course Level | Undergraduate |
| Course Type | |
| Mode of delivery | Face to face |
| Course Coordinator |
Assist. Prof. Dr. Miray İLHAN |
| Instructors | |
| Assistants | |
| Goals | It aims to analyze the concepts of bioavailability, bioequivalence and pharmacokinetics, determination methods, mathematical evaluations, formulation parameters affecting these concepts, and examination of blood-time data of drugs with mathematical models, compartment models and/or noncompartmental models. |
| Course Content | Terminology related to biopharmaceutical-pharmacokinetics, Pharmacokinetics, dosage form design relationship, Bioavailability and determination methods, its importance, Bioavailability enhancement recommendations, Importance of bioequivalence determination methods, Compartment models, Peeling Method |
| Learning Outcomes |
- Learns terminological concepts related to biopharmaceutics and pharmacokinetics. - Learns the concepts of bioavailability and bioequivalence. - Gains information about linear and nonlinear pharmacokinetics and determination. - Gains information about the analysis of pharmacokinetic parameters from blood data by peeling method. |
| Week | Topics | Learning Methods |
|---|---|---|
| 1. Week | Terminology about Biopharmaceutics and Pharmacokinetics | |
| 2. Week | Relationship of pharmacokinetic and dosage form design | |
| 3. Week | Relationship of pharmacokinetic and dosage form design | |
| 4. Week | Bioavailability analyses methods and importance | |
| 5. Week | Bioavailability analyses methods and importance | |
| 6. Week | Bioavailability enhancement suggestions | |
| 7. Week | Bioavailability enhancement suggestions | |
| 8. Week | Midterm | |
| 9. Week | Bioequivalence analysis methods and importance | |
| 10. Week | Bioequivalence enhancement suggestions | |
| 11. Week | Compartmental models | |
| 12. Week | Compartmental models | |
| 13. Week | Compartmental models | |
| 14. Week | Stripping / Peeling method | |
| 15. Week | Stripping / Peeling method |
| Modern Farmasötik Teknoloji, F. Acartürk, İ. Ağabeyoğlu, N. Çelebi, T. Değim, Z. Değim, T. Doğanay, S. Takka, F. Tırnaksız, Türk Eczacılar Birliği, Eczacılık Akademisi Yayını Yayın No: 1, Ankara, 2007. |
| Farmasötik Teknoloji, Temel Konular ve Dozaj Şekilleri, Ed.: Ayla Z. Gürsoy, Kontrollü Salım Sistemleri Derneği Yayını No: 2, İstanbul, 2004. |
| Bourne DWA, Pharmacokinetics, Ed: GS Banker, CT Rhodes, Modern Pharmacuetics, 4th ed., Marcel Dekker Inc., 2002 |
| Gibaldi M, Perrier D. Pharmacokinetics, 2nd edition, Marcel Dekker Inc., 1982 |
| Wagner JG, Fundamentals of Clinical Pharmacokinetics, Drug Intelligence Pub., 1979 |
| Program Requirements | Contribution Level | DK1 | DK2 | DK3 | DK4 | Measurement Method |
|---|
| 0 | 1 | 2 | 3 | 4 | 5 | |
|---|---|---|---|---|---|---|
| Course's Level of contribution | None | Very Low | Low | Fair | High | Very High |
| Method of assessment/evaluation | Written exam | Oral Exams | Assignment/Project | Laboratory work | Presentation/Seminar |
| Event | Quantity | Duration (Hour) | Total Workload (Hour) |
|---|---|---|---|
| Midterm 1 | 1 | 8 | 8 |
| Homework 1 | 1 | 5 | 5 |
| Final | 1 | 10 | 10 |
| Classroom Activities | 14 | 2 | 28 |
| Total Workload | 51 | ||
| ECTS Credit of the Course | 3.0 | ||
