| Course Title | Code | Semester | L+U Hour | Credits | ECTS |
|---|---|---|---|---|---|
| Pharmaceutical Chemistry II Laboratory | ECZ394 | 6. Semester | 0 + 4 | 2.0 | 2.0 |
| Prerequisites | None |
| Language of Instruction | Turkish |
| Course Level | Undergraduate |
| Course Type | |
| Mode of delivery | face to face |
| Course Coordinator |
Assist. Prof. Dr. Bahadır BÜLBÜL |
| Instructors |
Bahadır BÜLBÜL |
| Assistants | |
| Goals | Teaching theoretical and practical information about separation and purification methods used in drug analysis, various chromatographic techniques and determination of physical parameters. |
| Course Content | |
| Learning Outcomes |
- Gains knowledge about the definition of chromatography, classification of chromatographic techniques, principles of chromatographic techniques (adsorption, partition, ion exchange, gel filtration, reversed phase, ion pair and affinity chromatography). - Learns and applies the principles of paper chromatography, thin layer chromatography and column chromatography. - Have knowledge about ion exchange chromatography, gas chromatography and capillary electrophoresis methods. - Learns and applies high pressure liquid chromatography (HPLC). - Learns the separation of solid-solid and liquid-liquid mixtures. - Learns the determination methods of physical parameters such as molecular weight, density, melting and boiling point, refractive index and optical rotation angle and applies some of them. - Applies pharmacopoeia analysis. - Applies chromatographic methods in drug metabolism studies. |
| Week | Topics | Learning Methods |
|---|---|---|
| 1. Week | Demonstration: Chromatography and chromatographic techniques | |
| 2. Week | Demonstration: Determination of physicochemical parameters | |
| 3. Week | Demonstration: drug metabolism | |
| 4. Week | Determination of densities of solid and liquid compounds | |
| 5. Week | Separation of solid-solid mixtures | |
| 6. Week | Polarimetric and refractometric analysis | |
| 7. Week | Determination of melting and boiling point | |
| 8. Week | Separation of liquid-liquid mixtures | |
| 9. Week | Pharmacopeia analysis | |
| 10. Week | Pharmacopeia analysis | |
| 11. Week | Paper Chromatography, drug metabolism | |
| 12. Week | Column Chromatography | |
| 13. Week | HPLC experiment | |
| 14. Week | discussion, compensation |
| Farmasötik Kimya Laboratuvar Çalışmaları II, H.Ü. Eczacılık Fakültesi Farmasötik Kimya Anabilim Dalı Yayını, Ankara, 2004. |
| Stahl, E.,”Thin-layer Chromatography”, 2nd edition, Springer-Verlag, New York, 1969. |
| Miller, J.A., Neuzil, E.F., “Modern Experimental Organic Chemistry”, D.C. Heath and Company, Lexington, Massachusetts, 1982. |
| Ergenç, N., Gürsoy, A., Ateş, Ö.,”İlaçların Tanınması ve Kantitatif Tayini”, Matbaacılık, İstanbul, 1999. |
| Program Requirements | Contribution Level | DK1 | DK2 | DK3 | DK4 | DK5 | DK6 | DK7 | DK8 | Measurement Method |
|---|
| 0 | 1 | 2 | 3 | 4 | 5 | |
|---|---|---|---|---|---|---|
| Course's Level of contribution | None | Very Low | Low | Fair | High | Very High |
| Method of assessment/evaluation | Written exam | Oral Exams | Assignment/Project | Laboratory work | Presentation/Seminar |
| Event | Quantity | Duration (Hour) | Total Workload (Hour) |
|---|---|---|---|
| Midterm 1 | 1 | 1 | 1 |
| Homework 1 | 10 | 1 | 10 |
| Final | 1 | 2 | 2 |
| Practice | 1 | 10 | 10 |
| Classroom Activities | 14 | 2 | 28 |
| Total Workload | 51 | ||
| ECTS Credit of the Course | 2.0 | ||
