| Course Title | Code | Semester | L+U Hour | Credits | ECTS |
|---|---|---|---|---|---|
| Pharmaceutical Chemistry I | ECZ303 | 5. Semester | 3 + 0 | 3.0 | 3.0 |
| Prerequisites | None |
| Language of Instruction | Turkish |
| Course Level | Undergraduate |
| Course Type | |
| Mode of delivery | face to face |
| Course Coordinator |
Assist. Prof. Dr. Bahadır BÜLBÜL |
| Instructors |
Bahadır BÜLBÜL |
| Assistants | |
| Goals | The general aim of this course is to introduce the pharmaceutical chemistry course to the students; to inform the students about the difficulties / complexity and stages of drug design and methods to discover of lead compound; the steps and the procedures of rational drug design, computer aided/assisted drug design; molecular modification methods and quantitative structure-activity reletionship studies for the optimization of lead compound. |
| Course Content | |
| Learning Outcomes |
- Pharmaceutical chemistry: Description and history - Drug design, steps of drug design, methods to discover of lead compound, rational drug design and procedures of rational drug design; computer aided/assisted drug design and its principles - Methods for the optimization of lead compound by molecular modification techniques - The effect of physicochemical properties (such as partition and ionization) of drugs on their activities and quantitative structure-activity reletionship studies are the learning outcomesof this cours. |
| Week | Topics | Learning Methods |
|---|---|---|
| 1. Week | Drug and Organism | |
| 2. Week | Pharmacokinetic and Pharmacodynamic principles | |
| 3. Week | Makacromolecular targets and drug interactions | |
| 4. Week | Structure activity relationships | |
| 5. Week | Drug metabolism | |
| 6. Week | Introduction to nervous system and local anesthetics | |
| 7. Week | Sedative hypnotics | |
| 8. Week | Tranclining and Neuroleptic drugs | |
| 9. Week | Antidepressants | |
| 10. Week | Antiepileptic drugs | |
| 11. Week | Drugs used in the treatment of Alzheimer's and centrally acting muscle relaxants | |
| 12. Week | Antiparkinsonian drugs | |
| 13. Week | narcotic analgesics | |
| 14. Week | Nonsteroidal Anti-Inflammatory Drugs (NSAID) |
| “Organic Chemistry”T. W. Graham Solomons, Craig B. Fryhle ISBN : 0-471-19095-0, 7 th Edition |
| “Organic Chemistry” A Brief Course; Robert C. Atkins, Francis A.Carey |
| Keynotes in Organic Chemistry” Andrew F. Parsons ISBN: 9781119999140, 2nd Edition |
| “Medicinal Chemistry Laboratory Manual: Investigations in Biological Pharmaceutical Chemistry”, Charles Dickson ISBN-10: 0849318882, ISBN-13: 978-0849318887 |
| Program Requirements | Contribution Level | DK1 | DK2 | DK3 | DK4 | Measurement Method |
|---|
| 0 | 1 | 2 | 3 | 4 | 5 | |
|---|---|---|---|---|---|---|
| Course's Level of contribution | None | Very Low | Low | Fair | High | Very High |
| Method of assessment/evaluation | Written exam | Oral Exams | Assignment/Project | Laboratory work | Presentation/Seminar |
| Event | Quantity | Duration (Hour) | Total Workload (Hour) |
|---|---|---|---|
| Midterm 1 | 1 | 22.5 | 22.5 |
| Homework 1 | 1 | 1 | 1 |
| Quiz 1 | 1 | 1 | 1 |
| Final | 1 | 24 | 24 |
| Classroom Activities | 14 | 2 | 28 |
| Total Workload | 76.5 | ||
| ECTS Credit of the Course | 3.0 | ||
