Rapor Tarihi: 11.04.2026 13:01
| Course Title | Code | Language | Type | Semester | L+U Hour | Credits | ECTS |
|---|---|---|---|---|---|---|---|
| Cell Physiology And Signal Transduction | FZY501 | Turkish | Compulsory | 3 + 0 | 3.0 | 7.0 |
| Prerequisite Courses | |
| Course Level | Graduate |
| Mode of delivery | Face to face |
| Course Coordinator | Dr. Öğr. Üyesi Özge BEYAZÇİÇEK |
| Instructor(s) | Dr. Öğr. Üyesi Özge BEYAZÇİÇEK (Bahar), Dr. Öğr. Üyesi Özge BEYAZÇİÇEK (Güz) |
| Goals | To examine the physiological mechanisms of cell structure, cell organelles and cellular functions; to explain intracellular and intercellular signalling pathways, regulatory mechanisms and the physiological importance of cellular communication. |
| Course Content | Introduction to cell physiology and physiological concepts; Human body structure, Organelles, Organelles and Cell Cycle, Different Tissue Cells; Epithelial cells, Connective and support tissue cells, Muscle tissue cells, Endocrine cells, Lung cells, Blood tissue cells, Reproductive cells, Nerve tissue cells (Cell types found in the brain), Vision/Hearing/Smell/Taste and Touch cells, Cell Proliferation; Differentiated Cell Proliferation, Fibroblast Cell Proliferation, Endothelial Cell Proliferation, Smooth Muscle Cell Proliferation, Haematopoietic Cell Proliferation, Intestinal Epithelial Stem Cell Proliferation, Skin Stem Cell Proliferation, Skeletal Muscle Cell Proliferation, Stem Cell Differentiation, Cell Differentiation; Cell Adaptation Types (Atrophy, Hypertrophy, Hyperplasia, Dysplasia, Metaplasia), Cell Damage and its Causes, Definition of Inflammation, its Development and Symptoms, Acute and Chronic Inflammation, Lesion, Necrosis, Apoptosis Definitions, Cancer; Definition of cancer, Invasion, Metastasis, Genetic and molecular basis of cancer, Cancer-related genes, Oncogenes, Tumour suppressor genes, Types of cancer and their statistical distribution, Stem Cells; History of stem cells, Self-renewing stem cells, Differences between normal body cells and stem cells, Stages of stem cell development (totipotent, pluripotent, multipotent, unipotent) ,types of stem cells - according to their differentiation properties and where they are obtained (embryonic, adult and foetal), Umbilical cord blood and stem cells, Applications of stem cells, Apoptosis; Definition of programmed cell death, Definition of necrosis and its difference from apoptosis, Phosphatidylserine found in the apoptotic cell membrane, Caspases, Central regulators of apoptosis (Bcl-2 gene), Pro-apoptotic regulatory mechanisms, Pro-apoptotic regulatory proteins when activated, The mitochondrial pathway of apoptosis, Signalling pathways regulating apoptosis, Induction of apoptosis by p53, Growth factor deprivation, Intracellular signalling pathways, Extrinsic Apoptosis Pathway, Tumour Necrosis Factor-Fas, Autophagy, Physiological and Pathological Apoptosis, Insufficient and Excessive Apoptosis |
| # | Öğrenme Kazanımı |
| 1 | 1- To have knowledge about the general structure of the cell |
| 2 | 2- Be able to describe the structure and function of cell membranes and organelles. |
| 3 | 3- To explain cell proliferation and apoptosis |
| 4 | 4- To be able to describe intracellular and intercellular communication |
| Week | Topics/Applications | Method |
|---|---|---|
| 1. Week | Introduction to Cell Physiology and Physiological Concepts | Preparation, After Class Study, Presentation (Preparation) |
| 2. Week | Introduction to Cell Physiology and Physiological Concepts -II | Preparation, After Class Study, Presentation (Preparation) |
| 3. Week | The Cell, Its Functional Organisation and Organelles | Preparation, After Class Study, Presentation (Preparation) |
| 4. Week | Organelles and the Cell Cycle | Preparation, After Class Study, Presentation (Preparation) |
| 5. Week | Blood Tissue Cells | Preparation, After Class Study, Research, Presentation (Preparation) |
| 6. Week | Lung Tissue Cells | Preparation, After Class Study, Research, Presentation (Preparation) |
| 7. Week | Muscle tissue cells | Preparation, After Class Study, Presentation (Preparation) |
| 8. Week | Nerve System Cells | Preparation, After Class Study, Fieldwork |
| 9. Week | Sensory cells | Preparation, After Class Study, Research, Presentation (Preparation) |
| 10. Week | Female and Male Reproductive System Cells | Preparation, After Class Study, Presentation (Preparation) |
| 11. Week | Stem Cell | Preparation, After Class Study, Presentation (Preparation) |
| 12. Week | Apoptosis-I | Preparation, After Class Study, Research, Presentation (Preparation) |
| 13. Week | Apoptosis-II | Preparation, After Class Study, Research, Presentation (Preparation) |
| 14. Week | Cell Differentiation and Cancer | Preparation, After Class Study, Research, Presentation (Preparation) |
| No | Program Requirements | Level of Contribution | |||||
|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |||
| 1 | To have enough knowledge in Basic Medical Physiology and Basic Medical Sciences to support those physiology notions, as well as to evaluate and improve those knowledge. | ✔ | |||||
| 2 | To keep up with the literature in the field, and their knowledge and skills in their profession as well as to realize and apply lifelong learning process. | ✔ | |||||
| 3 | To design scientific research in their field and, to conduct that research individually or with their team. To have enough knowledge in statistic, to use necessary software and to offer solutions to problems | ✔ | |||||
| 4 | To know the importance of the collaboration with related medical science disciplines and, to use their knowledge and problem solving skills in the studies between those disciplines. | ✔ | |||||
| 5 | To write a report of a participated research as well as to publish or present that research in national and international meetings. | ✔ | |||||
| 6 | To use the technology of informatics and communication as much as the field demanded. | ✔ | |||||
| 7 | To have enough knowledge of laboratory safety and research ethics as well as to consider those values in data collection, data interpretation and its announcement phases. | ✔ | |||||
| 8 | To have enough skills and knowledge to use basic laboratory instruments as well as the sophisticated ones which are related to their research field. | ✔ | |||||
| 9 | To have enough skills and knowledge to use basic laboratory instruments as well as the sophisticated ones which are related to their research field. | ✔ | |||||
| 10 | To have skills of presentation and transmitting their knowledge. | ✔ | |||||
| 11 | To communicate and defend their original ideas with national and international scientists by using the way of writing, speaking and presenting. | ✔ | |||||
| Program Requirements | DK1 | DK2 | DK3 | DK4 |
|---|---|---|---|---|
| PY1 | 4 | 5 | 5 | 5 |
| PY2 | 4 | 4 | 4 | 5 |
| PY3 | 5 | 5 | 5 | 5 |
| PY4 | 5 | 5 | 5 | 5 |
| PY5 | 5 | 3 | 3 | 3 |
| PY6 | 5 | 5 | 5 | 5 |
| PY7 | 5 | 5 | 4 | 4 |
| PY8 | 5 | 3 | 3 | 3 |
| PY10 | 5 | 5 | 5 | 5 |
| PY11 | 5 | 3 | 2 | 1 |
| Ders Kitabı veya Notu | Ders Kitabı veya Ders Notu bulunmamaktadır. |
|---|---|
| Diğer Kaynaklar |
|
| ECTS credits and course workload | Quantity | Duration (Hour) | Total Workload (Hour) | |
|---|---|---|---|---|
|
Ders İçi |
Class Hours | 14 | 3 | 42 |
|
Ders Dışı |
Homework | 2 | 8 | 16 |
| Preparation, After Class Study | 14 | 6 | 84 | |
| Research | 1 | 18 | 18 | |
| Presentation (Preparation) | 16.5 | 1 | 16.5 | |
|
Sınavlar |
Final | 1 | 2 | 2 |
| Total Workload | 178.5 | |||
| *AKTS = (Total Workload) / 25,5 | ECTS Credit of the Course | 7.0 | ||
